Dr. Amit Mishra completed his M.Sc. in Biotechnology with honor’s from Devi Ahilya University, Indore. He then joined Ph.D. in Neuroscience at Cellular and Molecular Neuroscience Unit, under the supervision of Prof. Nihar Ranjan Jana (Current Position: Professor, Indian Institute of Technology Khargpur) from National Brain Research Centre, India (Established by Padma Sri, Padma Bhusan and Padma Vibhuhassan Prof. P.N Tandon and Shanti Swarup Bhatnagar Prize, Padma Shri Prof. Vijaylakshmi Rabindranath).
Dr. Mishra Ph.D. Thesis entitled “Understanding the molecular function of E6-AP-a putative E3 ubiquitin ligase mutated in Angelman mental Retardation Syndrome” was selected for BEST Ph.D. THESIS AWARD in Biological Sciences from Indian Society of Chemists and Biologists, India and also awarded by Indian Academy of Neuroscience for Best Presentation Award (IST Prize). He investigated the role of key players in protein quality control mechanism: E3 ubiquitin ligase and molecular chaperones. Understand the role of E6-AP E3 Ubiquitin Ligase in p53 (tumor suppressor protein) proteasomal degradation. He also observed p27Kip1 (Cyclin-dependent kinase inhibitor) ubiquitination and degradation is regulated by E6-AP E3 Ubiquitin Ligase through proteasomal degradation.
The major focus of Amit research projects has been the study of “Molecular Pathogenesis Mechanism of Various E3 Ubiquitin Ligases and Chaperones Implicated in Neurodegenerative Diseases, Neurodevelopmental Disorders, and Ageing”. In 2008, he moved to The Max Planck Institute of Biochemistry (Munich, Germany) as a post-doctoral fellow with Max Planck Society Fellowship, Germany in the laboratory of Prof. Ulrich Hartl.Here, he investigated the role of ribosomal associated chaperone in protein misfolding and aggregation. In 2010, he moved back to India and joined as a faculty at the Indian Institute of Technology Jodhpur and was awarded for prestigious “Ramalinganswami Fellowship” and “Innovative Young Biotechnologist Award” from the Department of Biotechnology, India. He is a recipient of “IGC- “Young Genetics Researcher Award”: presented by Nobel Laureate–Medicine (Prof. Harald zur Hausen) and Indian Father of Green Revolution (Prof. M. S. Swaminathan), Fellow Royal Society of London” at the young age and his candidature was also selected for the National Academy of Sciences, India (NASI)-Young Scientist Platinum Jubilee Award.
(Cover Page) Ayeman Amanullah, Arun Upadhyay, Vibhuti Joshi, Ribhav Mishra, Nihar Ranjan Jana and Amit Mishra* (2017) Progressing Neurobiological Strategies Against Proteostasis Failure: Challenges in Neurodegeneration
Progress in Neurobiology DOI:10.1016/j.pneurobio.2017.08.005
He was also awarded by Indian National Science Academy and Prof. Umakant Sinha Memorial Award of Indian Science Congress Association.His research work enlightens precise molecular mechanism of E3 ubiquitin ligases and molecular chaperones, their involvement in cellular quality control pathways and effect overall cellular homeostasis. Improved our existing knowledge about crucial mechanisms, which can provide new opportunities to modulate protein in cellular quality control mechanism in neurodegenerative diseases and aging that are caused by abnormal protein accumulation in cells. On his outstanding contribution in both research and academic career, he received very prestigious honors such as Max Planck Society Fellowship, Riken Brain Science Institute Fellowship, S. S. Parmar Foundation Prize USA, and Council of Scientific and Industrial Research (CSIR) fellowship.
However, the precise role of E3 ubiquitin ligases in cancer pathobiology is not clear. He finds various tumor suppressor crucial proteins as substrates of the E6-AP E3 ubiquitin ligase. This study improves our current understanding and sure help to better assimilate the oncogenic potential of E3S. For such of research he was honored by Board of Research in Nuclear Sciences (BRNS)-Bhabha Atomic Research Centre (BARC)-Young Scientist Research Award and The “Young Investigator Award 2017″ from Japan Neuroscience Society (JNS), Japan. Amit research acknowledging the efficiency of the cellular quality control system, it is expected that there might be an existence of early quality control system in cells, which is governed by E3 ubiquitin ligases.